Propylene Glycol(Pharma Grade)
Zhuhai PT Power Technology Co., Ltd. is a high-tech company focusing on LED Power Supply, established in 2008 which is committed to providing customers with a set of R&D, manufacture, sales and service to support LED lighting industry. The company has a workforce of over 500 employees, with its production facilities spread across several locations. PT Power Technology Co., Ltd. has received numerous awards for its innovative products and quality management systems.
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What Is Propylene Glycol(Pharma Grade)
A high-purity grade of monopropylene glycol for use in pharmaceutical (excipient only; ingredient of a pharmaceutical injectable application is not supported), food, cosmetic, personal care, flavor and fragrance, plus a variety of other applications.
Features of Propylene Glycol(Pharma Grade)
Hygroscopic Nature: Efficient Moisture Absorption
One of the key characteristics of propylene glycol is its hygroscopic nature, meaning it readily absorbs moisture from the air. This property is particularly advantageous in industries where moisture control is critical. In food products, propylene glycol helps maintain a desired level of moisture, extending shelf life and improving texture.
Low Freezing Point: Ideal for Antifreeze and Coolants
Propylene glycol’s low freezing point makes it an excellent choice for antifreeze and coolant applications. It can withstand extremely low temperatures without solidifying, making it ideal for systems that operate in harsh or cold environments. In automotive and industrial cooling systems, propylene glycol-based coolants help protect engines from freezing and ensure smooth operation even in subzero conditions. This property also extends to HVAC systems, where it prevents freezing in air conditioning and refrigeration units, ensuring consistent temperature regulation.
High Boiling Point: Ensuring Stability Across Applications
Propylene glycol has a high boiling point, which contributes to its stability under high temperatures. This makes it highly suitable for applications that involve exposure to heat, such as in certain industrial processes and engine coolants. Unlike some compounds that break down or evaporate when exposed to elevated temperatures, propylene glycol remains stable, providing reliable performance.
Solvent Properties: Effective Dissolution of Various Substances
Another key advantage of propylene glycol is its excellent solvent properties. It can dissolve a wide range of substances, including oils, resins, and flavor compounds. This makes it an indispensable ingredient in food, pharmaceuticals, and cosmetics. In the food industry, propylene glycol is used as a carrier for flavors, ensuring that ingredients blend smoothly and evenly. In cosmetics, it helps dissolve active ingredients, making them more bioavailable and effective. Additionally, its use in pharmaceuticals allows for the uniform distribution of medicinal compounds, contributing to the efficacy of various treatments.
Low Toxicity: Safe for Use in Food, Cosmetics, and Pharmaceuticals
One of the most important advantages of propylene glycol is its low toxicity, which allows it to be safely used in food, cosmetics, and pharmaceuticals. It is classified as Generally Recognized as Safe (GRAS) by the U.S. Food and Drug Administration (FDA), meaning it can be used in regulated quantities without posing health risks. Its safety profile makes it a common ingredient in products such as food additives, flavorings, skincare items, and oral medications. Consumers can feel confident that products containing propylene glycol are safe for regular use, even in sensitive applications like children's foods and personal care items.
Applications of Propylene Glycol(Pharma Grade)
Non-Toxic Antifreeze
Only within the past few years has propylene glycol been used in a new version of antifreeze that replaces ethylene glycol based formulations.
This change didn't happen because propylene glycol was better performing than ethylene glycol, but because it was less toxic.
Propylene glycol antifreeze, on the other hand, is a non-toxic alternative. This is because if it is consumed, it is converted into two harmless chemicals: acetic acid (also known as vinegar) and pyruvic acid (a normal production of the glucose-metabolism process). Propylene glycol is used in antifreeze because, like ethylene glycol, it lowers the freezing point of water by disrupting the formation of ice crystals.
Food Industry
Another testament to the non-toxic nature of PG is its use in the food industry where it serves as a humectant, solvent and preservative among other things. Propylene glycol has the E-Number E1520. One reason propylene glycol is used in various food products is because it doesn't react on its own, allowing it to do its job without affecting other ingredients.
Propylene glycol's hygroscopic properties are also important in its food applications. By attracting and holding water-based and oil-based substances, PG is able to provide homogenous distribution in a mixture.This means that it is able to distribute food colouring, for example, evenly. Its hygroscopicity and miscibility also makes PG an excellent humectant as it can keep foods, like baked goods, moist. This also helps to preserve them.
Pharmaceuticals
Propylene glycol is used in a range oforal, topical and intravenous medicines. It is also used as a drug stabiliser and as a solvent. Its miscibility with water enables PG to be used as a solvent for insoluble pharmaceutical formulations. Diazepam, for example, benefits for the miscible properties of propylene glycol. PG is used in a similar way during intravenous medications, where it helps the body absorb chemicals more efficiently. While there have been concerns over the toxicity of propylene glycol, it is important to remember that it breaks down in the body within 48 hours and forms no harmful crystals. This is why it is known as being non-bio-accumulative, as it doesn't build up in our bodies.
E-Cigarettes
E-cigarettes are the less harmful alternative to smoking. They work by heating a nicotine cartridge that contains liquid. This happens when the user begins inhaling. The e-liquid is transported from the cartridge to the atomiser, where cotton is usually used to soak it up. Heat caused by inhalation then converts the liquid to vapour that the individual exhales.
E-cigarettes contain several chemicals, the safety of which has come under dispute time and time again. Propylene glycol is one of these chemicals. The liquid that is used in an e-cigarette cartridge often contains vegetable glycerin and propylene glycol. These are also mixed with flavourings and nicotine.
Glycerin is a viscous substance, and its presence in e-liquid helps to make the vapour clouds thicker.However, its viscosity as a liquid could lead to the poor transportation of the e-liquid to the tomiser.Therefore,propylene glycol is added as a thinner.
Propylene glycol makes the e-liquid more easily absorbed by the cotton in the atomiser, and its low density prevents any residue from building up inside. PG is used in a similar way in smoke or fog machines. lf you've ever been to a theatrical performance or music concert where artificial smoke is used, the clouds more often than not contain propylene glycol.
1. Food Grade Propylene Glycol
Definition: Food-grade propylene glycol liquid meets the standards set by regulatory bodies like the FDA (Food and Drug Administration) for use in food products.
Purity: High purity, similar to USP grade but specifically approved for food applications. Typically 99.5% pure or higher, free from harmful contaminants.
2. USP Grade propylene glycol liquid(Pharmaceutical Grade)
Definition: USP (United States Pharmacopeia) grade propylene glycol meets the stringent standards set by the USP for purity, safety, and quality. It is the highest quality of propylene glycol available.
Purity: Very high purity, typically 99.5% or higher.Free from harmful impurities that could affect human health.
3. Industrial Grade Propylene Glycol
Definition: Industrial-grade propylene glycol is intended for non-food and non-pharmaceutical applications, where the highest purity is not required.
Purity: Lower purity compared to USP and food grade, but still typically above 95%. May contain higher levels of impurities that are acceptable for industrial uses but not for food or pharmaceutical products.
4. Dipropylene Glycol (DPG)
DPG - Fragrance Grade
Definition: A high-purity grade of dipropylene glycol specifically designed for use in fragrances and cosmetics.
Purity: High purity, typically greater than 99%.Low odor and colorless, making it ideal for fragrance applications.
DPG - Industrial Grade
Definition: A lower-purity grade of dipropylene glycol is used in various industrial applications.
Purity: Lower purity compared to fragrance grade, but typically still around 95-99%.May contain impurities acceptable for industrial uses.
Tips Of Use Propylene Glycol(Pharma Grade)
Sealed storage: Since propylene glycol is easy to absorb moisture, the container needs to be kept sealed during storage, and stored in a cool, dry, well-ventilated place to avoid direct sunlight.
Pay attention to fire and explosion prevention: Although propylene glycol is not flammable, it can decompose to generate flammable gas under heating and high temperature, and form an explosive mixture with oxygen. Therefore, it is necessary to pay attention to fire and explosion prevention when using it.
Low toxicity and low risk: When using propylene glycol, you should comply with the safe use regulations of chemicals and avoid contact with skin and eyes. After contact, it should be cleaned in time. If swallowed, it should be sent to the hospital for treatment immediately.
Reasonable storage: Propylene glycol needs to be stored separately from strong oxidants, and the storage container should comply with relevant regulations. Iron and copper containers cannot be used.
Pay attention to environmental protection: Environmental protection regulations should be followed during use to avoid polluting the environment.
How to Choose Propylene Glycol(Pharma Grade)
Differentiate the types of propylene glycol: 1,2-propylene glycol and 1,3-propylene glycol are common in the market. 1,2-propylene glycol is a chemical reagent with potential safety issues; while 1,3-propylene glycol is made from corn sugar fermentation, also known as corn moisturizer, is a natural and safe ingredient suitable for all skin types. Be careful to distinguish when selecting products.
Pay attention to the source of the product: If it is bio-based propylene glycol, you can understand how it is produced, such as acrolein hydration, hydrogenation, ethylene oxide hydroxyl method, etc. Different production methods may affect the nature and quality of the product.
Product quality standards: Refer to relevant quality standards, such as pharmaceutical-grade propylene glycol has clear standards, including properties, identification, inspection (acidity, chloride, related substances, etc.), content determination, etc. Understanding these standards helps to determine whether the quality of the product is qualified.
Safety: Especially when used in cosmetics or products that come into contact with the skin, pay attention to the possible side effects of propylene glycol on the skin. People with sensitive facial skin may experience discomfort symptoms such as burning, itching, erythema, and chloasma with certain propylene glycol products. If such symptoms occur, they should stop using the product. If you are allergic to propylene glycol, it is not suitable to use products containing this ingredient.
Manufacturer reputation: Choose products from well-known and reputable manufacturers, whose product quality and stability may be more guaranteed.
Application field matching: Choose according to the specific application field needs. For example, in cosmetics, consider its performance as a moisturizer, emollient, skin feel improver or solvent; in food, pay attention to the use limits and regulations.
Product specifications and packaging: According to actual use needs, choose appropriate specifications and packaging forms to ensure easy use and reduce waste.
Price factors: Under the premise of meeting quality and needs, you can compare the prices of different products, but don't just take price as the only choice.
Frequently Asked Questions